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Document 3140
DOCN M94A3140
TI Natural history of HIV-infection in Bulgaria.
DT 9412
AU Plochev KS; Dicov I; Duchovnicova T; Radinov A; Brankova J; Penkova K;
Valcova I; Doganova I; M. M. A.-Centre of immunology, Sofia, Bulgaria.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):144 (abstract no. PB0003). Unique
Identifier : AIDSLINE ICA10/94369435
AB OBJECTIVE: An analysis of the course of the HIV-infection in Bulgaria
for the period 1986-93 was performed. METHODS: The patients were exposed
to epidemiologecal, clinical, paraclinical and immunological analysis.
The main methods used were flow cytometry, laser nephelometry, CAT,
sonography, and standart clinical procedures. For statistical analysis
was used a software product Microsoft Excel for Windows 5.0. RESULTS:
For the period of investigation at least 4 mln bulgarians and 72000
foreigners were tested. 124 HIV+ bulgarians/0.003% of the tested
population/and 90 foreigners were found. 24 infected bulgarians
developed a clinic of AIDS and 20 of them died. Clinical investigations
showed that 68% of HIV-infected suffered of oportunistic infections,
distributed as follow: 36%-bacterial, 28%-fungal, 20%-viral, and
16%-parasitic infections. 6% developed neoplasias and 26% were
asymptomatic. Mycobacterial and pneumocystis carinii infections were
very rare. 84 HIV-infected were followed up by immunophenotyping.
DISCUSSIONS AND CONCLUSIONS: 1. HIV-infections has spread with a low
intensity in Bulgaria. 2. Epidemiological data showed that the infection
is developed by African type. 3. It is viewed very high mortality on the
base of late recognizing. 4. Clinical and immunological approach for
control of the infection allow us to precisely define the clinical stage
of the disease.
DE Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/MORTALITY/
PHYSIOPATHOLOGY AIDS-Related Opportunistic Infections/EPIDEMIOLOGY/
PHYSIOPATHOLOGY Bulgaria/EPIDEMIOLOGY Comparative Study Human HIV
Infections/COMPLICATIONS/*EPIDEMIOLOGY/*PHYSIOPATHOLOGY HIV
Seropositivity/*EPIDEMIOLOGY/*PHYSIOPATHOLOGY Neoplasms/COMPLICATIONS
Prevalence MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).